Synthesis of Steroid Derivatives for In Vitro Diagnostics.

0496998 - ÚCHP 2019 CZ eng C - Conference Paper (international conference)
Kos, Martin - Váňa, Lubomír - Žádný, Jaroslav - Storch, Jan
Synthesis of Steroid Derivatives for In Vitro Diagnostics.
Book of Abstracts. Louvain-la-Neuve: Université catholique de Louvain, 2018 - (Gaigneux, E.), s. 6, č. článku P 32. ISBN N.
[Advances in Organic, Bioorganic and Pharmaceutical Chemistry LIBLICE 2018 /53./. Lázně Bělohrad (CZ), 02.11.2018-04.11.2018]
R&D Projects: GA MPO(CZ) FV20061
Institutional support: RVO:67985858
Keywords : steriod * dyagnostics * sythesis
OECD category: Organic chemistry

This work is focused on the synthesis of novel steroidal androgen derivatives consisting of a steroidal skeleton, a spacer and imidazole ring or a primary amine functional group. The starting material for the synthesis is represented by commercial available hydroxy-androgens, which are further modified. First, the hydroxyl group is attached to the spacer and then connected to the desired imidazole or the protected primary amine. The above described derivatives will be utilized for development of analytical kits for a determination of the free steroid hormone.
Permanent Link: http://hdl.handle.net/11104/0289610