Changing the threshold-Signals and mechanisms of mast cell priming

0494578 - ÚMG 2019 RIV GB eng J - Journal Article
Hálová, Ivana - Ronnberg, E. - Dráberová, Lubica - Vliagoftis, H. - Nilsson, G.P. - Dráber, Petr
Changing the threshold-Signals and mechanisms of mast cell priming.
Immunological Reviews. Roč. 282, č. 1 (2018), s. 73-86. ISSN 0105-2896. E-ISSN 1600-065X
R&D Projects: GA ČR(CZ) GA17-20255S; GA ČR(CZ) GA17-20915S
Institutional support: RVO:68378050
Keywords : cell priming * chemokines * cytokine receptors * cytokines * high-affinity IgE receptor * mast cell
OECD category: 3.2 Clinical medicine
Impact factor: 11.292, year: 2018

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (Fc epsilon RIs). Aggregation of Fc epsilon RIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4,6 and33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E-2, sphingosine-1-phosphate, and beta-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.
Permanent Link: http://hdl.handle.net/11104/0287679