Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals

0490250 - FZÚ 2019 RIV GB eng J - Journal Article
Villa, I. - Villa, Ch. - Monguzzi, A. - Babin, Vladimir - Tervoort, E. - Nikl, Martin - Niederberger, M. - Torrente, Y. - Vedda, A. - Lauria, A.
Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals.
Nanoscale. Roč. 10, č. 17 (2018), s. 7933-7940. ISSN 2040-3364. E-ISSN 2040-3372
EU Projects: European Commission(XE) 690599 - ASCIMAT
Institutional support: RVO:68378271
Keywords : cellular imaging * luminescence
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 6.970, year: 2018

Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu3+-doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for cellular optical imaging and as radiosensitive materials for clinical treatment. Furthermore, viability and biocompatibility tests on artificially stressed cell cultures reveal their ability to buffer reactive oxygen species, proposing an anti-cytotoxic feature interesting for biomedical applications.
Permanent Link: http://hdl.handle.net/11104/0284513