Beta-glucans and cholesterol

0488761 - MBÚ 2021 GR eng J - Journal Article
Šíma, Petr - Vannucci, Luca - Větvička, V.
Beta-glucans and cholesterol.
International Journal of Molecular Medicine. Roč. 41, č. 4 (2018), s. 1799-1808. ISSN 1107-3756. E-ISSN 1791-244X
Institutional support: RVO:61388971
Keywords : cholesterol * beta-glucans * diet
OECD category: Microbiology
Impact factor: 2.928, year: 2018
Method of publishing: Open access
https://www.spandidos-publications.com/10.3892/ijmm.2018.3411

Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various side effects. -glucans are linear unbranched polysaccharides found in various natural sources, such as mushrooms. Due to their structure they are able to interact with innate immunity receptors, however they also act as dietary fibers in the digestive tract. As there are two forms of -glucans, insoluble and soluble forms, they are able to interact with lipids and biliary salts in the bowel and consequently reduce cholesterol levels. Therefore, they may be developed as a suitable therapeutic option to treat patients with dyslipidemia, as they are natural molecules that do not induce any significant side effects. The current review discusses the evidence supporting the effects of -glucans on cholesterol levels.


Permanent Link: http://hdl.handle.net/11104/0283298