Lipidomic Analysis: From Archaea to Mammals

0488721 - MBÚ 2019 RIV US eng J - Journal Article
Řezanka, Tomáš - Kolouchová, I. - Gharwalová, L. - Palyzová, Andrea - Sigler, Karel
Lipidomic Analysis: From Archaea to Mammals.
Lipids. Roč. 53, č. 1 (2018), s. 5-25. ISSN 0024-4201. E-ISSN 1558-9307
R&D Projects: GA ČR(CZ) GA17-00027S
Institutional support: RVO:61388971
Keywords : Algae * Animals * Archaea
OECD category: Microbiology
Impact factor: 2.144, year: 2018

Lipids are among the most important organic compounds found in all living cells, from primitive archaebacteria to flowering plants or mammalian cells. They form part of cell walls and constitute cell storage material. Their biosynthesis and metabolism play key roles in faraway topics such as biofuel production (third-generation biofuels produced by microorganisms, e.g. algae) and human diseases such as adrenoleukodystrophy, Zellweger syndrome, or Refsum disease. Current lipidomic analysis requires fast and accurate processing of samples and especially their characterization. Because the number of possible lipids and, more specifically, molecular species of lipids is of the order of hundreds to thousands, it is necessary to process huge amounts of data in a short time. There are two basic approaches to lipidomic analysis: shotgun and liquid chromatography-mass spectometry. Both methods have their pros and cons. This review deals with lipidomics not according to the type of ionization or the lipid classes analyzed but according to the types of samples (organisms) under study. Thus, it is divided into lipidomic analysis of archaebacteria, bacteria, yeast, fungi, algae, plants, and animals.
Permanent Link: http://hdl.handle.net/11104/0283263