Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

0488571 - ÚACH 2019 RIV US eng J - Journal Article
Hynek, Jan - Zelenka, J. - Rathouský, Jiří - Kubát, Pavel - Ruml, T. - Demel, Jan - Lang, Kamil
Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria.
ACS Applied Materials and Interfaces. Roč. 10, č. 10 (2018), s. 8527-8535. ISSN 1944-8244. E-ISSN 1944-8252
R&D Projects: GA ČR(CZ) GA16-15020S
Institutional support: RVO:61388980 ; RVO:61388955
Keywords : antibacterial coating * biofilm * covalent organic framework * photodynamic * porphyrin * singlet oxygen
OECD category: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impact factor: 8.456, year: 2018

Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O 2 ( 1 Δ g ), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O 2 ( 1 Δ g ) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.
Permanent Link: http://hdl.handle.net/11104/0283142


Research data: ACS publications