Nuclear bodies: news insights into structure and function

0487072 - ÚMG 2018 RIV GB eng J - Journal Article
Staněk, David - Fox, A.H.
Nuclear bodies: news insights into structure and function.
Current Opinion in Cell Biology. Roč. 46, léto (2017), s. 94-101. ISSN 0955-0674. E-ISSN 1879-0410
R&D Projects: GA ČR GA15-00790S; GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : rna-binding proteins * cajal bodies * smn complex * human-cells * in-vivo * human telomerase * coiled bodies * lncrna neat1 * u1 snrnp * body
OECD category: Cell biology
Impact factor: 10.015, year: 2017

The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid-liquid phase separation, which are transforming our picture of nuclear body formation.
Permanent Link: http://hdl.handle.net/11104/0281753