Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice

0485754 - BFÚ 2018 RIV CZ eng J - Journal Article
Hofer, Michal - Hoferová, Zuzana - Dušek, L. - Souček, Karel - Gruzdev, A.
Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice.
Physiological Research. Roč. 66, č. 4 (2017), s. 673-676. ISSN 0862-8408. E-ISSN 1802-9973
Institutional support: RVO:68081707
Keywords : irradiated mice * g-csf * increases * inhibitor
OECD category: Cell biology
Impact factor: 1.324, year: 2017

We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
Permanent Link: http://hdl.handle.net/11104/0280698