The catholic taste of broad tapeworms multiple routes to human infection

0485159 - BC 2018 RIV AU eng J - Journal Article
Waeschenbach, A. - Brabec, Jan - Scholz, Tomáš - Littlewood, D. T. J. - Kuchta, Roman
The catholic taste of broad tapeworms multiple routes to human infection.
International Journal for Parasitology. Roč. 47, č. 13 (2017), s. 831-843. ISSN 0020-7519. E-ISSN 1879-0135
R&D Projects: GA ČR GAP506/12/1632
Institutional support: RVO:60077344
Keywords : Diphyllobothriidea * Diphyllobothriosis * Phylogeny * Sparganosis * Systematics * Taxonomic revision * Mitochondrial * Nuclear
OECD category: Zoology
Impact factor: 3.078, year: 2017

Broad tapeworms (Cestoda: Diphyllobothriidea) are the principal agents of widespread food-borne cestodosis. Diphyllobothriosis and diplogonoporosis, caused by members of the genera Diphyllobothrium, Diplogonoporus and Adenocephalus, are the most common fish cesto-doses with an estimated 20 million people infected worldwide, and has seen recent (re)emergences in Europe due to the increasing popularity of eating raw or undercooked fish. Sparganosis is a debilitating and potentially lethal disease caused by the larvae of the genus Spirometra, which occurs throughout much of the (sub)tropics and is caused by the consumption of raw snakes and frogs, and drinking water contaminated by infected copepods. Both dis eases are caused by several species, but the frequency by which the transition to humans has occurred has never been studied. Using a phylogenetic framework of 30 species based on large and small nuclear ribosomal RNA subunits (ssrDNA, IsrDNA), large subunit mitochondrial ribosomal RNA (rrnL) and cytochrome coxidase subunit I (cox1), we hypothesize that humans have been acquired as accidental hosts four times across the tree of life of diphyllobothriideans. However, polytomies prevent an unambiguous reconstruction of the evolution of intermediate and definitive host use. The broad host spectrum and the frequency with which switching between major host groups appears to have occurred, may hold the answer as to why accidental human infection occurred multiple times across the phylogeny of diphyllobothriideans. In this study Diplogonoporus is determined to be the junior synonym of Diphyllobothrium.
Permanent Link: http://hdl.handle.net/11104/0280233