Letter to the Editor. Acetic acid is elevated in the exhaled breath of cystic fibrosis patients

0484021 - ÚFCH JH 2018 RIV NL eng J - Journal Article
Španěl, Patrik - Sovová, Kristýna - Dryahina, Kseniya - Doušová, T. - Dřevínek, P. - Smith, D.
Letter to the Editor. Acetic acid is elevated in the exhaled breath of cystic fibrosis patients.
Journal of Cystic Fibrosis. Roč. 16, č. 5 (2017), e17-e18. ISSN 1569-1993. E-ISSN 1873-5010
R&D Projects: GA ČR(CZ) GA14-14534S
Institutional support: RVO:61388955
Keywords : acetic acid * cystic fibrosis transmembrane conductance regulator * volatile organic compound
OECD category: Analytical chemistry
Impact factor: 3.858, year: 2017

Breath analysis is becoming an attractive non-invasive aid to
clinical diagnosis and therapeutic monitoring and can provide
more insight into pathology of cystic fibrosis (CF) and related
respiratory infections. Selected ion flow tube mass spectrometry,
SIFT-MS [1] allows the analysis of single breath
exhalations on line and also by the off-line analysis of breath
samples collected into bags. SIFT-MS breath analysis has been
directed previously towards identification of volatile biomarkers
of bacterial infection, including Pseudomonas
aeruginosa that commonly infect the lungs of CF patients.
Thus, hydrogen cyanide, HCN, has been identified as a breath
metabolite compound specific (99%) to P. aeruginosa [2].
Permanent Link: http://hdl.handle.net/11104/0279181