Inflammation as target in cancer therapy.

0483220 - MBÚ 2018 RIV GB eng J - Journal Article
Marelli, G. - Sica, A. - Vannucci, Luca - Allavena, P.
Inflammation as target in cancer therapy.
Current Opinion in Pharmacology. Roč. 35, August 2017 (2017), s. 57-65. ISSN 1471-4892. E-ISSN 1471-4973
Institutional support: RVO:61388971
Keywords : cancer therapy * cancer-promoting inflammation * Tumour-Associated Macrophages
OECD category: Microbiology
Impact factor: 6.313, year: 2017

Cells of the innate immunity infiltrating tumour tissues promote, rather than halt, cancer cell proliferation and distant spreading. Tumour-Associated Macrophages (TAMs) are abundantly present in the tumour milieu and here trigger and perpetrate a state of chronic inflammation which ultimately supports disease development and contributes to an immune-suppressive environment. Therapeutic strategies to limit inflammatory cells and their products have been successful in pre-clinical tumour models. Early clinical trials with specific cytokine and chemokine inhibitors, or with strategies designed to target TAMs, are on their way in different solid malignancies. Partial clinical responses and stabilization of diseases were observed in some patients, in the absence of significant toxicity. These encouraging results open new perspectives of combination treatments aimed at reducing cancer-promoting inflammation to maximize the anti-tumour efficacy.
Permanent Link: http://hdl.handle.net/11104/0278610