Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer

0481441 - ÚEM 2018 RIV GB eng J - Journal Article
Gregor, A. - Filová, Eva - Novák, M. - Kronek, J. - Chlup, H. - Buzgo, M. - Hefka Blahnová, Veronika - Lukášová, Věra - Bartoš, M. - Nečas, A. - Hošek, J.
Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer.
Journal of Biological Engineering. Roč. 11, oct (2017), s. 31. ISSN 1754-1611. E-ISSN 1754-1611
R&D Projects: GA MŠMT(CZ) LO1309; GA ČR GA16-14758S
Institutional support: RVO:68378041
Keywords : tissue engineering * bio-fabrication * scaffold
OECD category: Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Impact factor: 5.256, year: 2017

In tissue engineering, scaffolds are used for cell culture. Biodegradable scaffolds gradually degrade and are replaced by new formed tissue. Automatic manufacturing, e.g. by Rapid Prototyping, enables to prepare scaffolds of precise structure, shape and size. In the work we have tested commercially available 3D printer and polylactic acid was used as a tested material. Structures with different geometry have been prepared and tested with osteosarcomas cells. Moreover, biomechanical properties of the scaffolds have been tested. Porosity lower than 90% did not affect cell proliferation, and scaffolds demonstrated better biomechanical properties. Our work showed possibilities and limitations during the scaffolds preparation using Rapid Prototyping.
Permanent Link: http://hdl.handle.net/11104/0278104