MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis

0480904 - ÚEM 2018 RIV GB eng J - Journal Article
Schneiderová, B. - Naccarati, Alessio - Pardini, Barbara - Rosa, F. - Di Gaetano, C. - Jirásková, Kateřina - Opattová, Alena - Levý, M. - Veskrna, K. - Veškrnová, V. - Buchler, T. - Landi, S. - Vodička, Pavel - Vymetálková, Veronika
MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis.
Mutagenesis. Roč. 32, č. 5 (2017), s. 533-542. ISSN 0267-8357. E-ISSN 1464-3804
R&D Projects: GA MZd(CZ) NV15-26535A; GA MŠMT(CZ) LD14050; GA MZd(CZ) NV15-27580A; GA ČR(CZ) GA17-16857S
Institutional support: RVO:68378041
Keywords : excision-repair genes * bladder-cancer * tumor-growth
OECD category: Biochemistry and molecular biology
Impact factor: 2.840, year: 2017

Here we provide the first evidence that variations in potential miRNA target binding sites in the 3UTR of PARP1 gene may modulate CRC risk and prognosis after therapy. We investigated eight miRSNPs (rs1804191, rs397768, rs41116 in APC, rs1137918, s227091, rs4585 in ATM, rs712, rs1137282, rs61764370 in KRAS, rs8674 in PARP1 and rs16950113 in SMAD7) for their association with CRC risk in a case–control study (1111 cases and 1469 healthy controls). The role of these miRSNPs was also investigated in relation to clinical outcome on a subset of patients with complete follow-up.
Permanent Link: http://hdl.handle.net/11104/0276796