Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients

0480900 - ÚEM 2019 RIV US eng J - Journal Article
Kroupa, Michal - Polívková, Z. - Rachakonda, S. - Schneiderová, M. - Vodenková, Soňa - Buchler, T. - Jirásková, Kateřina - Urbanová, Markéta - Vodičková, Ludmila - Hemminki, K. - Kumar, R. - Vodička, Pavel
Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients.
Genes Chromosomes & Cancer. Roč. 57, č. 2 (2018), s. 61-69. ISSN 1045-2257. E-ISSN 1098-2264
R&D Projects: GA MZd(CZ) NV15-27580A; GA ČR(CZ) GA15-14789S; GA MŠMT(CZ) LD14050
Institutional support: RVO:68378041
Keywords : tert promoter mutations * mutagen sensitivity * colorectal-cancer * breast-cancer * DNA-damage
OECD category: Gastroenterology and hepatology
Impact factor: 2.940, year: 2018

Disruption of genomic integrity due to deficient DNA repair capacity and telomere shortening constitute hallmarks of malignant diseases. Incomplete or deficient repair of DNA double-strand breaks (DSB) is manifested by chromosomal aberrations and their frequency reflects inter-individual differences of response to exposure to mutagenic compounds. We have investigated above parameters in blood lymphocytes from patients with breast and colorectal cancer. Our results suggest that altered DSB repair measured by sensitivity towards mutagen in PBL occurs particularly in CRC carcinogenesis. Irrespective of cancer type, telomere shortening may be associated with a decreased capacity to repair DSB.
Permanent Link: http://hdl.handle.net/11104/0287043