Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

0479718 - FGÚ 2018 RIV CA eng J - Journal Article
Ravingerová, T. - Farkašová, V. - Griecsová, L. - Muráriková, M. - Čarnická, S. - Lonek, L. - Ferko, M. - Slezák, J. - Zálešák, M. - Adameová, A. - Khandelwal, V. K. M. - Lazou, A. - Kolář, František
Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?
Canadian Journal of Physiology and Pharmacology. Roč. 95, č. 10 (2017), s. 1204-1212. ISSN 0008-4212. E-ISSN 1205-7541
Grant - others:AV ČR(CZ) SAV-15-15
Program: Bilaterální spolupráce
Institutional support: RVO:67985823
Keywords : ischemia–reperfusion * myocardial infarction * remote preconditioning * innate cardioprotection * cell signaling
OECD category: Physiology (including cytology)
Impact factor: 2.210, year: 2017

Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing “remote” PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.
Permanent Link: http://hdl.handle.net/11104/0275675