Interfacing microchannel separations with electrospray mass spectrometry

0478667 - ÚIACH 2018 CZ eng D - Thesis
Foret, František
Interfacing microchannel separations with electrospray mass spectrometry.
Ústav analytické chemie AV ČR, v. v. i. Defended: Brno : Ústav analytické chemie AV ČR, v. v. i. 26.09.2017. - Brno: Ústav analytické chemie AV ČR, v. v. i, 2017. 175 s.
Institutional support: RVO:68081715
Keywords : electrospray mass spectrometry * microchannel separations * electrospray ionization
Subject RIV: CB - Analytical Chemistry, Separation

This dissertation describes development and application of interfaces for coupling of
microchannel separations with electrospray mass spectrometry. The text, based on
20 selected publications, covers mainly electrophoretic separations coupled to
electrospray mass spectrometry for both capillary arrangements and chip based
devices. The papers document my research activities in electrospray mass
spectrometry interfacing over the past 24 years and were selected from over 100 other
studies published during the 1993 – 2016. The presented work is highly experimental
and since each arrangement has its own specifics, I have divided the papers into two
separate sections (although both parts of the work have overlapped in time). The first
part deals with capillary electrophoresis-mass spectrometry and includes eleven
research papers covering various aspects of interfacing of capillary electrophoresis,
performed in standard fused silica capillaries, with electrospray mass spectrometry.
The second part documents the evolution of different approaches and instrumentation
for on-line coupling of microfabricated devices with electrospray mass spectrometry.
Permanent Link: http://hdl.handle.net/11104/0274775