An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors

0477421 - ÚIACH 2018 RIV FR eng J - Journal Article
Vettorazzi, M. - Angelina, E. - Lima, S. - Goněc, T. - Otevřel, J. - Marvanová, P. - Padrtová, T. - Mokrý, P. - Bobáľ, P. - Acosta, L. M. - Palma, A. - Cobo, J. - Bobálová, Janette - Csollei, J. - Malik, I. - Alvarez, S. - Spiegel, S. - Jampílek, J. - Enriz, R. D.
An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.
European Journal of Medicinal Chemistry. Roč. 139, OCT (2017), s. 461-481. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:68081715
Keywords : sphingosine kinase 1 inhibitors * bioassays * molecular modelling * virtual screening
OECD category: Analytical chemistry
Impact factor: 4.816, year: 2017

Sphingosine kinase 1 is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. The main objective of this work was to find new and
more potent inhibitors for this enzyme possessing different structural scaffolds than those of the known inhibitors.
Permanent Link: http://hdl.handle.net/11104/0273776