Study of Asymmetric Stereoselective Hydrogenation in Presence of Ionic Liquid in Microfluidic Chip Reactor.

0475758 - ÚCHP 2018 SK eng C - Conference Paper (international conference)
Vychodilová, Hana - Stavárek, Petr - Hejda, Stanislav - Pěnkavová, Věra - Bendová, Magdalena - Vlček, Dalibor - Klusoň, Petr
Study of Asymmetric Stereoselective Hydrogenation in Presence of Ionic Liquid in Microfluidic Chip Reactor.
Proceedings. Bratislava: Slovak Society of Chemical Engineering, 2017 - (Blahušiak, M.; Mihal, M.), s. 739. ISBN 978-80-89597-58-1.
[International Conference of SSCHE /44./. Demänovská dolina (SK), 22.05.2017-26.05.2017]
R&D Projects: GA ČR GA15-04790S
Institutional support: RVO:67985858
Keywords : microfluidic chip reactor * stereoselective hydrogenation * ionic liquid
OECD category: Chemical process engineering

In recent years, there have been several successful attempts of microreactor application to production of specialty chemicals [1,2] mainly for pharma and other related industry fields. In this study, we focused on the application of microfluidic chip reactor to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex [3] immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase, and performed inside of a microfluidic chip reactor. A presence of ionic liquid (quarternary ammonium salts) allows for an easy separation of this catalyst via its pseudo-immobilization.
Permanent Link: http://hdl.handle.net/11104/0272389