Mechanisms of hormonal regulation of the peripheral circadian clock in the colon

0473974 - FGÚ 2018 RIV US eng J - Journal Article
Polidarová, Lenka - Houdek, Pavel - Sládek, Martin - Novosadová, Zuzana - Pácha, Jiří - Sumová, Alena
Mechanisms of hormonal regulation of the peripheral circadian clock in the colon.
Chronobiology International. Roč. 34, č. 1 (2017), s. 1-16. ISSN 0742-0528. E-ISSN 1525-6073
R&D Projects: GA ČR(CZ) GA14-07711S; GA ČR(CZ) GA13-08304S
Institutional support: RVO:67985823
Keywords : circadian clock * colon * entrainment
OECD category: Physiology (including cytology)
Impact factor: 2.643, year: 2017

Colonic function is controlled by an endogenous clock that allows the colon to optimize its function on the daytime basis. For the first time, this study provided evidence that the clock is synchronized by rhythmic hormonal signals. In rat colon, adrenalectomy decreased and repeated applications of dexamethasone selectively rescued circadian rhythm in the expression of the clock gene Per1. Dexamethasone entrained the colonic clock in explants from mPer2Luc mice in vitro. In contrast, pinealectomy had no effect on the rat colonic clock, and repeated melatonin injections were not able to rescue the clock in animals maintained in constant light. Additionally, melatonin did not entrain the clock in colonic explants from mPer2Luc mice in vitro. However, melatonin affected rhythmic regulation of Nr1d1 gene expression in vivo. The findings provide novel insight into possible beneficial effects of glucocorticoids in the treatment of digestive tract-related diseases, greatly exceeding their anti-inflammatory action.
Permanent Link: http://hdl.handle.net/11104/0271074