Reactions of copper(II), nickel(II), and zinc(II) acetates with a new water-soluble 4-phenylthiosemicarbazone Schiff base ligand: synthesis, characterization, unexpected cyclization, antimicrobial, antioxidant, and anticancer activities

0473836 - FZÚ 2018 RIV GB eng J - Journal Article
Hosseini-Yazdi, S.A. - Mirzaahmadi, A. - Khandar, A.A. - Eigner, Václav - Dušek, Michal - Mahdavi, M. - Soltani, S. - Lotfipour, F. - White, J.
Reactions of copper(II), nickel(II), and zinc(II) acetates with a new water-soluble 4-phenylthiosemicarbazone Schiff base ligand: synthesis, characterization, unexpected cyclization, antimicrobial, antioxidant, and anticancer activities.
Polyhedron. Roč. 124, Mar (2017), s. 156-165. ISSN 0277-5387. E-ISSN 1873-3719
R&D Projects: GA ČR(CZ) GA15-12653S; GA MŠMT LO1603
EU Projects: European Commission(XE) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : antimicrobial * antioxidant * cytotoxicity * thiosemicarbazone * water-soluble Schiff base
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 2.067, year: 2017

A new Schiff base thiosemicarbazone ligand with aqueous solubility, namely, sodium 3-{[(anilinocarbonothioyl)hydrazono]methyl}-4-hydroxy benzene sulfonate (NaH2L) was synthesized by condensation of 4-phenylthiosemicarbazide and sodium salicylaldehyde-5-sulfonate (NaSalSO3) and characterized by elemental analysis, spectroscopic methods (UV–Vis, 1H NMR, FTIR) and electrospray ionization mass spectrometry. A co-crystal (Na(H2L)·Na(SalSO3)) of NaH2L and NaSalSO3 was prepared which confirmed the expected structure of the ligand. Reactions of NaH2L·0.5H2O with copper(II), nickel(II), and zinc(II) acetates were investigated under reflux conditions in methanol to produce following complexes [Cu2(Lcycl)2(H2O)2]·2H2O (CuLcycl), Ni(HL)(H2O)3 (NiL), and Zn(HL)(H2O)3 (ZnL).
Permanent Link: http://hdl.handle.net/11104/0270963