2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound

0473521 - MBÚ 2018 RIV US eng J - Journal Article
Filippopoulou, K. - Papaevgeniou, N. - Lefakia, M. - Paraskevopoulou, A. - Biedermann, David - Křen, Vladimír - Chondrogianni, N.
2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
Free Radical Biology and Medicine. Roč. 103, FEB 2017 (2017), s. 256-267. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA MŠMT(CZ) LD15081
Institutional support: RVO:61388971
Keywords : 2,3-dehydrosilybin A/B * Anti-aging * Anti-aggregation
OECD category: Biochemistry and molecular biology
Impact factor: 6.020, year: 2017

Aging is an unavoidable process characterized by gradual failure of homeostasis that constitutes a critical risk factor for several age-related disorders. It has been unveiled that manipulation of various key pathways may decelerate the aging progression and the triggering of age-related diseases. As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here we analyze the role of 2,3-dehydrosilybin A/B (DHS A/B), a minor component of silymarin used in a plethora of dietary supplements. This flavonolignan is well-known for its anti-oxidative and neuroprotective properties, among others. We demonstrate that DHS A/B confers oxidative stress resistance not only in human primary cells but also in the context of a multi-cellular aging model, namely Caenorhabditis elegans (C. elegans) where it also promotes lifespan extension. We reveal that these DHS A/B outcomes are FGT-1 and DAF-16 dependent. We additionally demonstrate the anti-aggregation properties of DHS A/B in human cells of nervous origin but also in nematode models of Alzheimer's disease (AD), eventually leading to decelerated progression of AD phenotype. Our results identify DHS A/B as the active component of silymarin extract and propose DHS A/B as a candidate anti-aging and anti-aggregation compound.
Permanent Link: http://hdl.handle.net/11104/0270644