0473328 - ÚVGZ 2017 RIV RO eng J - Journal Article
Balaita, L. - Cadinoiu, A. N. - Postolache, P. - Šafaříková, Miroslava - Popa, M.
Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications.
Journal of Optoelectronics and Advanced Materials. Roč. 17, č. 7-8 (2015), s. 1198-1209. ISSN 1454-4164. E-ISSN 1841-7132
Grant - others:Ministery of Education of the Czech Republic(CZ) MP0701
Institutional support: RVO:67179843
Keywords : acid-modified chitosan * drug-delivery * nanoparticles * release * microparticles * microspheres * stability * alcohol * complex * Chitosan * Poly(vinyl alcohol) * Magnetic particles * Ionic crosslinking * Covalent crosslinking * Drug delivery
Subject RIV: EH - Ecology, Behaviour
Impact factor: 0.383, year: 2015 ; AIS: 0.078, rok: 2015

This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology.
Permanent Link: http://hdl.handle.net/11104/0270477