Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J

0473165 - ÚMG 2017 RIV US eng J - Journal Article
Plachý, Jiří - Reinišová, Markéta - Kučerová, Dana - Šenigl, Filip - Stepanets, Volodymyr - Hron, Tomáš - Trejbalová, Kateřina - Elleder, Daniel - Hejnar, Jiří
Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J.
Journal of Virology. Roč. 91, č. 3 (2017), č. článku e02002. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA ČR GA13-30983S; GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : ALV-J * antiretroviral resistance * Na+/H+ exchanger * New World quail * retroviral receptor
OECD category: Virology
Impact factor: 4.368, year: 2017

The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World quails. The embryo fibroblasts of New World quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World quails and establish a natural reservoir of circulating virus with a potential for further evolution.
Permanent Link: http://hdl.handle.net/11104/0270328