0472719 - ÚMG 2017 RIV DE eng J - Journal Article
Fabian, Peter - Pantzartzi, Chrysoula - Kozmiková, Iryna - Kozmik, Zbyněk
vox homeobox gene: a novel regulator of midbrain-hindbrain boundary development in medaka fish?
Development Genes and Evolution. Roč. 226, č. 2 (2016), s. 99-107. ISSN 0949-944X. E-ISSN 1432-041X
R&D Projects: GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : Midbrain-hindbrain boundary * vox * medaka * Heat shock element * fgf8 * Gene regulatory network
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.422, year: 2016 ; AIS: 0.679, rok: 2016
DOI: https://doi.org/10.1007/s00427-016-0533-8

The midbrain-hindbrain boundary (MHB) is one of the key organizing centers of the vertebrate central nervous system (CNS). Its patterning is governed by a well-described gene regulatory network (GRN) involving several transcription factors, namely, pax, gbx, en, and otx, together with signaling molecules of the Wnt and Fgf families. Here, we describe the onset of these markers in Oryzias latipes (medaka) early brain development in comparison to previously known zebrafish expression patterns. Moreover, we show for the first time that vox, a member of the vent gene family, is expressed in the developing neural tube similarly to CNS markers. Overexpression of vox leads to profound changes in the gene expression patterns of individual components of MHB-specific GRN, most notably of fgf8, a crucial organizer molecule of MHB. Our data suggest that genes from the vent family, in addition to their crucial role in body axis formation, may play a role in regionalization of vertebrate CNS.
Permanent Link: http://hdl.handle.net/11104/0269949