The Biology and Therapeutic Applications of Mesenchymal Cells

0472194 - ÚEM 2018 RIV CZ eng M - Monography Chapter
Jendelová, Pavla - Machová-Urdzíková, Lucia - Syková, Eva
The role of mesenchymal stromal cells in spinal cord injury.
The Biology and Therapeutic Applications of Mesenchymal Cells. Oxford: Wiley-Blackwell, 2017 - (Atkinson, K.), s. 714-729. ISBN 978-1-118-90751-1
R&D Projects: GA MŠMT(CZ) LO1309
Institutional support: RVO:68378041
Keywords : mesenchymal stromal cells * bone marrow * adipose tissue * umbilical cord * spinal cord injury * clinical trials * therapeutic use * paracrine effect
OECD category: Neurosciences (including psychophysiology

Spinal cord injury (SCI) is one of the most devastating diseases that affects patients and their families for the rest of their lives. Among many treatments being developed for SCI, the placement of different types of grafts embedded with cell populations into areas of damage has been one of the most commonly used
regenerative approaches ,attracting scientists and physicians for the last 15 years. Stem/stromal cells are able to secrete a large repertoire of signaling molecules, including anti-inflammatory cytokines and growth factors, which may modulate the inhibitory environment of SCI while increasing trophic support to the resident cells. The chapter describes the pathology of spinal cord injury, the use of mesenchymal stromal cells derived from different sources in the treatment of SCI and their potential modifications and manipulations to reinforce their paracrine effect on neural tissue regeneration.

Permanent Link: http://hdl.handle.net/11104/0272797