Gene-specific sex effects on eosinophil infiltration in leishmaniasis

0472109 - ÚMG 2017 RIV GB eng J - Journal Article
Slapničková, Martina - Volkova, Valeriya - Čepičková, Marie - Kobets, Tetyana - Šíma, Matyáš - Svobodová, M. - Demant, P. - Lipoldová, Marie
Gene-specific sex effects on eosinophil infiltration in leishmaniasis.
Biology of Sex Differences. Roč. 7, podzim (2016), č. článku 59. E-ISSN 2042-6410
R&D Projects: GA ČR(CZ) GA14-30186S; GA ČR GP13-41002P; GA MŠMT LH12049; GA ČR GA16-22346S
Institutional support: RVO:68378050
Keywords : Leishmania major * Mouse model * Eosinophii infiltration * Genetic control * QTL * Sex influence
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.635, year: 2016

Background: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance.
Permanent Link: http://hdl.handle.net/11104/0269454