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Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

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    0471975 - BFÚ 2017 RIV US eng J - Journal Article
    Janovská, P. - Poppová, L. - Plevová, K. - Plesingerova, E. - Behal, M. - Kaucká, M. - Ovesná, P. - Hlozkova, M. - Borský, M. - Stehlíková, O. - Brychtová, Y. - Doubek, M. - Machalova, M. - Baskar, S. - Kozubík, Alois - Pospíšilová, Š. - Pavlová, Š. - Bryja, Vítězslav
    Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia.
    Clinical Cancer Research. Roč. 22, č. 2 (2016), s. 459-469. ISSN 1078-0432. E-ISSN 1557-3265
    Institutional support: RVO:68081707
    Keywords : receptor tyrosine kinase * cd38 expression * mutation status * cll cells
    Subject RIV: BO - Biophysics
    Impact factor: 9.619, year: 2016

    Purpose: ROR1, a receptor in the noncanonical Wnt/planar cell polarity (PCP) pathway, is upregulated in malignant B cells of chronic lymphocytic leukemia (CLL) patients. It has been shown that the Wnt/PCP pathway drives pathogenesis of CLL, but which factors activate the ROR1 and PCP pathway in CLL cells remains unclear.
    Permanent Link: http://hdl.handle.net/11104/0269334

     
     
Number of the records: 1  

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