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Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets

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    0467813 - MBÚ 2017 RIV US eng J - Journal Article
    Butler, J. E. - Santiago-Mateo, K. - Wertz, N. - Sun, X. - Šinkora, Marek - Francis, D.
    Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets.
    Developmental and Comparative Immunology. Roč. 65, December (2016), s. 340-351. ISSN 0145-305X. E-ISSN 1879-0089
    R&D Projects: GA ČR GA15-02274S
    Institutional support: RVO:61388971
    Keywords : Germfree animals * Ileal Peyers patches * Immunoglobulin A
    Subject RIV: EC - Immunology
    Impact factor: 3.218, year: 2016

    The Heal Peyers patches (IPP) of newborn germfree (GF) piglets were isolated into blind loops and the piglets colonized with a defined probiotic microflora. After 5 weeks, IgA levels in the intestinal lavage (IL) of loop piglets remained at GF levels and IgM comprised similar to 70% while in controls, IgA levels were elevated 5-fold and comprised similar to 70% of total Igs. Loop piglets also had. reduced serum IgA levels suggesting the source of serum IgA had been interrupted. The isotype profile for loop contents was intermediate between that in the IL of GF and probiotic controls. Surprisingly, colonization alone did not result in repertoire diversification in the IPP. Rather, colonization promoted pronounced proliferation of fully switched IgA(+)IgM(-) B cells in the IPP that supply early, non-diversified "natural" SIgA antibodies to the gut lumen and a primary IgA response in serum.
    Permanent Link: http://hdl.handle.net/11104/0266212

     
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