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Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs

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    0466904 - ÚMCH 2017 RIV NL eng J - Journal Article
    Mokhodoeva, O. - Vlk, M. - Málková, E. - Kukleva, E. - Mičolová, P. - Štamberg, K. - Šlouf, Miroslav - Dzhenloda, R. - Kozempel, J.
    Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs.
    Journal of Nanoparticle Research. Roč. 18, č. 10 (2016), s. 1-12, č. článku 301. ISSN 1388-0764. E-ISSN 1572-896X
    R&D Projects: GA MZd(CZ) NV16-30544A; GA TA ČR(CZ) TE01020118; GA MŠMT(CZ) LO1507
    Institutional support: RVO:61389013
    Keywords : magnetic nanoparticles * radium * sorption
    Subject RIV: CD - Macromolecular Chemistry
    Impact factor: 2.020, year: 2016

    The use of superparamagnetic iron oxide nanoparticles (SPIONs) and radiolabelled nanoparticles (NPs) has grown considerably over the recent years, and the SPIONs labelled with medicinal radionuclides offer new opportunities in multimodal diagnostics and in the drug-delivery systems for targeted alpha-particle therapy (TAT) driven by magnetic field gradient or by biologically active moieties bound on NPs shell. However, the mechanisms of NPs radiolabelling are not studied substantially and still remain unclear, even though the way of label attachment directly implies the stability of the label-nanoparticle construct. Since the 223Ra was the first clinically approved alpha-emitter, it is a promising nuclide for further development of its targeted carriers. We report here on the study of 223Ra uptake by the Fe3O4SPIONs, together with an attempt to propose the 223Ra uptake mechanism by the Fe3O4NPs in the presence of a phosphate buffer a typical formulation medium, under the pseudo-equilibrium conditions. Further, the in vitro stability tests of the prepared [223Ra]Fe3O4NPs were performed to estimate the 223Ra label stability. The potential use of 223Ra-labelled SPIONs in theranostic applications is also discussed.
    Permanent Link: http://hdl.handle.net/11104/0265087

     
     
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