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Voltammetric Determination of Tumor Biomarkers for Neuroblastoma (Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindole-3-acetic Acid) at Screen-printed Carbon Electrodes
- 1.0466719 - ÚFCH JH 2018 RIV DE eng J - Journal Article
Makrlíková, Anna - Ktena, E. - Economou, A. - Fischer, J. - Navrátil, Tomáš - Barek, J. - Vyskočil, V.
Voltammetric Determination of Tumor Biomarkers for Neuroblastoma (Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindole-3-acetic Acid) at Screen-printed Carbon Electrodes.
Electroanalysis. Roč. 29, č. 1 (2017), s. 146-153. ISSN 1040-0397. E-ISSN 1521-4109
Institutional support: RVO:61388955
Keywords : Homovanillic acid * Vanillylmandelic acid * 5-Hydroxyindole-3-acetic acid
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Impact factor: 2.851, year: 2017
Three tumor biomarkers (homovanillic acid
(HVA), vanillylmandelic acid (VMA), and 5-hydroxyindole-
3-acetic acid (5-HIAA)) have been determined by
differential pulse voltammetry (DPV) at screen-printed
carbon electrodes (SPCEs). As an optimum medium for
all three analytes, Britton-Robinson buffer (0.04 mol·L 1,
pH 3.0) was used. Dependencies of the peak current on
the concentration of a biomarker were linear in the concentration
range from 0.2 to 100 mmol·L 1 for all the
tested compounds, with the limits of quantification
0.8 mmol·L 1 for homovanillic acid, 0.2 mmol·L 1 for vanillylmandelic
acid, and 0.4 mmol·L 1 for 5-hydroxyindole-
3-acetic acid. Moreover, it was verified that the
newly developed methods can be used for simultaneous
determination of HVA and VMA in mixture.
Permanent Link: http://hdl.handle.net/11104/0264962
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