Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility\n

0466487 - FGÚ 2017 RIV NL eng J - Journal Article
Kopová, Ivana - Stráský, J. - Harcuba, P. - Landa, Michal - Janeček, M. - Bačáková, Lucie
Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility
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Materials Science & Engineering C-Materials for Biological Applications. Roč. 60, Mar 1 (2016), s. 230-238. ISSN 0928-4931. E-ISSN 1873-0191
R&D Projects: GA ČR(CZ) GAP107/12/1025
Institutional support: RVO:67985823 ; RVO:61388998
Keywords : elastic modulus * alloy hardening * cell growth * osteogenic cell differentiation * bone implants
Subject RIV: EI - Biotechnology ; Bionics; BI - Acoustics (UT-L)
Impact factor: 4.164, year: 2016

Beta titanium alloys are promising materials for load-bearing orthopaedic implants due to their excellent corrosion resistance and biocompatibility, low elastic modulus and moderate strength. Metastable beta-Ti alloys can be hardened via precipitation of the alpha phase; however, this has an adverse effect on the elastic modulus. Small amounts of Fe (0-2 wt.%) and Si (0-1 wt.%) were added to Ti-35Nb-7Zr-6Ta (TNZT) biocompatible alloy to increase its strength in beta solution treated condition. Fe and Si additions were shown to cause a significant increase in tensile strength and also in the elastic modulus (from 65 GPa to 85 GPa). However, the elastic modulus of TNZT alloy with Fe and Si additions is still much lower than that of widely used Ti-6A1-4V alloy (115 GPa), and thus closer to that of the bone (10-30 GPa). Si decreases the elongation to failure, whereas Fe increases the uniform elongation thanks to increased work hardening. Primary human osteoblasts cultivated for 21 days on TNZT with 0.5Si + 2Fe (wt.%) reached a significantly higher cell population density and significantly higher collagen I production than cells cultured on the standard Ti-6A1-4V alloy. In conclusion, the Ti-35Nb-7Zr-6Ta-2Fe-0.5Si alloy proves to be the best combination of elastic modulus, strength and also biological properties, which makes it a viable candidate for use in load-bearing implants.
Permanent Link: http://hdl.handle.net/11104/0264770