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Comparative study on toxicity of extracellularly biosynthesized and laboratory synthesized CdTe quantum dots
- 1.0465910 - ÚVGZ 2018 RIV NL eng J - Journal Article
Komínková, M. - Milosavljevic, V. - Vítek, Petr - Polanská, H. - Číhalová, K. - Dostálová, S. - Hynstová, V. - Guran, R. - Kopel, P. - Richtera, L. - Masarik, M. - Brtnický, M. - Kynický, J. - Zítka, O. - Adam, V.
Comparative study on toxicity of extracellularly biosynthesized and laboratory synthesized CdTe quantum dots.
Journal of Biotechnology. Roč. 241, JAN (2017), s. 193-200. ISSN 0168-1656. E-ISSN 1873-4863
R&D Projects: GA MŠMT(CZ) LO1415
Research Infrastructure: CzeCOS II - 90061
Institutional support: RVO:67179843
Keywords : Quantum dots * Biosynthesis * Escherichia coli (E. coli) * CdTe * Toxicity
OECD category: Environmental biotechnology
Impact factor: 2.533, year: 2017
Nanobiosynthesis belongs to the most recent methods for synthesis of nanoparticles. This type of synthesis
provides many advantages including the uniformity in particle shape and size. The biosynthesis
has also a significant advantage regarding chemical properties of the obtained particles. In this study, we
characterized the basic properties and composition of quantum dots (QDs), obtained by the extracellular
biosynthesis by Escherichia coli. Furthermore, the toxicity of the biosynthesized QDs was compared to
QDs prepared by microwave synthesis. The obtained results revealed the presence of cyan CdTe QDs after
removal of substantial amounts of organic compounds, which stabilized the nanoparticle surface. QDs
toxicity was evaluated using three cell lines Human Foreskin Fibroblast (HFF), Human Prostate Cancer
cells (PC-3) and Breast Cancer cells (MCF-7) and the MTT assay. The test revealed differences in the toxicity
between variants of QDs, varying about 10% in the HFF and 30% in the MCF-7 cell lines. The toxicity of
the biosynthesized QDs to the PC-3 cell lines was about 35% lower in comparison with the QDs prepared
by microwave synthesis.
Permanent Link: http://hdl.handle.net/11104/0265967
Number of the records: 1