Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring

0463864 - MBÚ 2017 RIV US eng J - Journal Article
Antvorskov, J.C. - Josefsen, K. - Haupt-Jorgensen, M. - Fundová, Petra - Funda, David P. - Buschard, K.
Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring.
Journal of Diabetes Research. Roč. 2016, July (2016), s. 3047574. ISSN 2314-6745. E-ISSN 2314-6753
R&D Projects: GA ČR GA15-24487S
Institutional support: RVO:61388971
Keywords : ISLET AUTOIMMUNITY * RISK * MICE
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 2.717, year: 2016

Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (P < 0.0001) in the gluten-free group.
Permanent Link: http://hdl.handle.net/11104/0263058