Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies

0463618 - MBÚ 2017 RIV US eng J - Journal Article
Podholová, K. - Plocek, V. - Rešetárová, Stanislava - Kučerová, H. - Hlaváček, Otakar - Váchová, Libuše - Palková, Z.
Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies.
OncoTarget. Roč. 7, č. 13 (2016), s. 15299-15314. ISSN 1949-2553
R&D Projects: GA ČR(CZ) GA15-08225S; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) EE2.3.30.0003
Institutional support: RVO:61388971
Keywords : mitochondrial retrograde signaling * development and differentiation * ageing and longevity
Subject RIV: EE - Microbiology, Virology
Impact factor: 5.168, year: 2016

Mitochondrial retrograde signaling mediates communication from altered mitochondria to the nucleus and is involved in many normal and pathophysiological changes, including cell metabolic reprogramming linked to cancer development and progression in mammals. The major mitochondrial retrograde pathway described in yeast includes three activators, Rtg1p, Rtg2p and Rtg3p, and repressors, Mks1p and Bmh1p/Bmh2p. Using differentiated yeast colonies, we show that Mks1p-Rtg pathway regulation is complex and includes three branches that divergently regulate the properties and fate of three specifically localized cell subpopulations via signals from differently altered mitochondria.
Permanent Link: http://hdl.handle.net/11104/0263047