Sugared biomaterial binding lectins: achievements and perspectives

0462996 - MBÚ 2017 RIV GB eng J - Journal Article
Bojarová, Pavla - Křen, Vladimír
Sugared biomaterial binding lectins: achievements and perspectives.
Biomaterials Science. Roč. 4, č. 8 (2016), s. 1142-1160. ISSN 2047-4830. E-ISSN 2047-4849
R&D Projects: GA ČR GC15-02578J
Institutional support: RVO:61388971
Keywords : C-TYPE LECTINS * AMPHIPHILIC JANUS GLYCODENDRIMERS * BIOMEDICALLY RELEVANT LECTINS
Subject RIV: CE - Biochemistry
Impact factor: 4.210, year: 2016

Lectins, a distinct group of glycan-binding proteins, play a prominent role in the immune system ranging from pathogen recognition and tuning of inflammation to cell adhesion or cellular signalling. The possibilities of their detailed study expanded along with the rapid development of biomaterials in the last decade. The immense knowledge of all aspects of glycan-lectin interactions both in vitro and in vivo may be efficiently used in bioimaging, targeted drug delivery, diagnostic and analytic biological methods. Practically applicable examples comprise photoluminescence and optical biosensors, ingenious three-dimensional carbohydrate microarrays for high-throughput screening, matrices for magnetic resonance imaging, targeted hyperthermal treatment of cancer tissues, selective inhibitors of bacterial toxins and pathogen-recognising lectin receptors, and many others.
Permanent Link: http://hdl.handle.net/11104/0263320