Real-space path integration is impaired in Alzheimer’s disease and mild cognitive impairment

0461568 - FGÚ 2017 RIV NL eng J - Journal Article
Mokrišová, I. - Laczó, J. - Andel, R. - Gažová, I. - Vyhnálek, M. - Nedělská, Z. - Levčík, David - Cerman, J. - Vlček, Kamil - Hort, J.
Real-space path integration is impaired in Alzheimer’s disease and mild cognitive impairment.
Behavioural Brain Research. Roč. 307, Jul 1 (2016), s. 150-158. ISSN 0166-4328. E-ISSN 1872-7549
Institutional support: RVO:67985823
Keywords : Alzheimer disease * mild cognitive impairment * spatial navigation * hippocampus * path integration
Subject RIV: FH - Neurology
Impact factor: 3.002, year: 2016

In a newly developed Arena Path Integration Task, we testes subjects suffering Alzheimer’s Disease and amnestic mild cognitive impairment in a navigation without vision to a previously seen goals and back to the start. Both groups of patients were impaired relative to healthy controls in returning back to the start position and their impairment was related to the medial temporal and parietal cortex volumes. Our results suggest that even navigation without vision is impaired in these patients, possibly as a function of medial temporal and parietal cortex neurodegeneration.
Permanent Link: http://hdl.handle.net/11104/0261181