Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity

0461365 - FZÚ 2017 RIV NL eng J - Journal Article
Kaman, Ondřej - Dědourková, T. - Koktan, Jakub - Kuličková, Jarmila - Maryško, Miroslav - Veverka, Pavel - Havelek, R. - Královec, K. - Turnovcová, Karolína - Jendelová, Pavla - Schröfel, A. - Svoboda, L.
Silica-coated manganite and Mn-based ferrite nanoparticles: a comparative study focused on cytotoxicity.
Journal of Nanoparticle Research. Roč. 18, č. 4 (2016), 1-18, č. článku 100. ISSN 1388-0764. E-ISSN 1572-896X
R&D Projects: GA ČR GA15-10088S
Institutional support: RVO:68378271 ; RVO:68378041
Keywords : magnetic nanoparticles * manganite * ferrite * in vitro toxicity * stem cells
OECD category: Condensed matter physics (including formerly solid state physics, supercond.); Acoustics (UEM-P)
Impact factor: 2.020, year: 2016

In vitro toxicity of manganite nanoparticles was thoroughly analysed and compared with Mn-Zn ferrite nanoparticles. Nanoparticles of La0.63Sr0.37MnO3 manganite were prepared by two distinct methods, namely the molten salt synthesis and the traditional sol-gel route, whereas nanoparticles of Mn0.61Zn0.42Fe1.97O4 ferrite, selected as a comparative material, were synthesized by a new procedure under hydrothermal conditions. Magnetic cores were coated with silica, and several samples of manganite nanoparticles with different thicknesses of silica shell were prepared. The products were analysed by using TEM, DLS, measurement of the zeta-potential measurements, IR spectroscopy, and SQUID magnetometry. The silica-coated products were subjected to a robust evaluation of their cytotoxicity by four different methods. The results clearly indicated superior properties of the Mn-Zn ferrite.
Permanent Link: http://hdl.handle.net/11104/0261803