Lateral resolution of desorption nanoelectrospray: a nanospray tip without nebulizing gas as a source of primary charged droplets

0460597 - MBÚ 2017 RIV GB eng J - Journal Article
Hartmanová, L. - Lorencová, I. - Volný, M. - Fryčák, P. - Havlíček, Vladimír - Chmelíčková, Hana - Ingr, T. - Lemr, K.
Lateral resolution of desorption nanoelectrospray: a nanospray tip without nebulizing gas as a source of primary charged droplets.
Analyst. Roč. 141, č. 7 (2016), s. 2150-2154. ISSN 0003-2654. E-ISSN 1364-5528
R&D Projects: GA ČR(CZ) GAP206/12/1150
Institutional support: RVO:61388971 ; RVO:68378271
Keywords : IONIZATION MASS-SPECTROMETRY * ELECTROSPRAY-IONIZATION * AMBIENT CONDITIONS
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 3.885, year: 2016

Desorption nanoelectrospray (nanoDESI) was described in 2007 and it represents a miniaturized version of desorption electrospray without the assistance of the nebulizing gas. Compared to DESI, a nanoelectrospray tip (2 +/- 1 mu m I.D.) generates primary charged droplets of smaller sizes and lower spray liquid flow rates. This is the first report on utilization of nanoDESI for mass spectrometry imaging (MSI). Its new coupling with a Q-TOF instrument allowed faster mass spectra acquisition (4 Hz) essential for MSI of fine surface details. To evaluate nanoDESI potential for mass spectrometry imaging, etched glass substrates with Rhodamine B patterns of different dimensions were prepared.
Permanent Link: http://hdl.handle.net/11104/0260628