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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
- 1.0459551 - FGÚ 2017 RIV US eng J - Journal Article
Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat.
Oxidative Medicine and Cellular Longevity. Roč. 2016, č. 2016 (2016), s. 9814038. ISSN 1942-0900. E-ISSN 1942-0994
R&D Projects: GA MZd(CZ) NV15-25396A
Institutional support: RVO:67985823
Keywords : nuclear factor-kB * nitric oxide * reactive oxygen species * heart * hereditary hypertriglyceridemic rats
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.593, year: 2016
Activation of nuclear factor-kB by increased production of reactive oxygen species (ROS) might induce expression of different antioxidant enzymes and nitric oxide synthase (NOS) isoforms. NF-kB inhibition in hereditary hypertriglyceridemic rats led to decreased ROS degradation by superoxide dismutase and to increased cardiac oxidative damage and elevated blood pressure. Under these conditions increased NO generation may represent a counterregulatory mechanism activate by ROS.
Permanent Link: http://hdl.handle.net/11104/0259737
Number of the records: 1