Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario

0458559 - BFÚ 2017 RIV DE eng J - Journal Article
Šponer, Judit E. - Šponer, Jiří - Nováková, Olga - Brabec, Viktor - Šedo, O. - Zdráhal, Z. - Costanzo, G. - Pino, S. - Saladino, R. - Di Mauro, E.
Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario.
Chemistry - A European Journal. Roč. 22, č. 11 (2016), s. 3572-3586. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GA14-12010S; GA ČR(CZ) GA13-08273S; GA ČR(CZ) GBP206/12/G151
Institutional support: RVO:68081707
Keywords : formamide * nucleobases * nucleotides
Subject RIV: BO - Biophysics
Impact factor: 5.317, year: 2016

50years after the historical Miller-Urey experiment, the formamide-based scenario is perhaps the most powerful concurrent hypothesis for the origin of life on our planet besides the traditional HCN-based concept. The information accumulated during the last 15years in this topic is astonishingly growing and nowadays the formamide-based model represents one of the most complete and coherent pathways leading from simple prebiotic precursors up to the first catalytically active RNA molecules. In this work, we overview the major events of this long pathway that have emerged from recent experimental and theoretical studies, mainly concentrating on the mechanistic, methodological, and structural aspects of this research.
Permanent Link: http://hdl.handle.net/11104/0258818