Newborns health in the Danube Region: Environment, biomonitoring, interventions and economic benefits in a large prospective birth cohort study

0458317 - ÚEM 2017 RIV US eng J - Journal Article
Andersen, Z.J. - Šrám, Radim - Ščasný, M. - Gurzau, E.S. - Fucic, A. - Gribaldo, L. - Rössner ml., Pavel - Rössnerová, Andrea - Kohlová, M.B. - Máca, V. - Zvěřinová, I. - Gajdošová, D. - Moshammer, H. - Rudnai, P. - Knudsen, L. E.
Newborns health in the Danube Region: Environment, biomonitoring, interventions and economic benefits in a large prospective birth cohort study.
Environment International. Roč. 88, mar. (2016), s. 112-122. ISSN 0160-4120. E-ISSN 1873-6750
Institutional support: RVO:68378041
Keywords : birth cohort * environment * biomonitoring * air pollution * danube region * childhood health
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.088, year: 2016

BACKGROUND:
The EU strategy for the Danube Region addresses numerous challenges including environment, health and socioeconomic disparities. Estimating the burden of environmental exposures on early-life health is a growing research area in Europe which has major public health implications, but the data from the Danube Region are largely missing.
AIM:
This review presents an inventory of current environmental challenges, related early-life health risks, and knowledge gaps in the Danube Region, based on publicly available databases, registers, and literature, as a rationale for a new integrated project.
METHODS:
Experts in environmental epidemiology, human biomonitoring and social science in collaboration with clinicians propose to establish a new large multi-center birth cohort of mother-child pairs from Danube countries, measure biomarkers of exposure and health in biological samples at birth, collect centrally measured climate, air and water pollution data, conduct pre- and postnatal surveys on lifestyle, indoor exposures, noise, occupation, socio-economic status, risk-averting behavior, and preferences; and undertake clinical examinations of children at and after birth. Effects of multiple environmental exposures on fetal and child growth, respiratory, allergic, immunologic, and neurodevelopmental health outcomes will be estimated.
CONCLUSIONS:
The proposed project would provide novel estimates of the burden of early childhood diseases attributable to environmental exposures and assess health impacts of different intervention scenarios in the Danube Region.


Permanent Link: http://hdl.handle.net/11104/0258600