Number of the records: 1
Cholesterol and fat lowering with hydrophobic polysaccharide derivatives
- 1.0457794 - ÚŽFG 2016 RIV GB eng J - Journal Article
Čopíková, J. - Taubner, T. - Tůma, J. - Synytsya, A. - Dušková, Dagmar - Marounek, Milan
Cholesterol and fat lowering with hydrophobic polysaccharide derivatives.
Carbohydrate Polymers. Roč. 116, č. 1 (2015), s. 207-214. ISSN 0144-8617. E-ISSN 1879-1344
Institutional support: RVO:67985904
Keywords : hydrophobically modified polysaccharides * structure * thermal analysis
Subject RIV: CE - Biochemistry
Impact factor: 4.219, year: 2015
Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine. It was found that modified polysaccharides have high affinity to cholesterol. By contrast, cholestyramine was effective only in cholate sorption.
Permanent Link: http://hdl.handle.net/11104/0258155
Number of the records: 1