In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions

0457461 - ÚFE 2016 RIV US eng C - Conference Paper (international conference)
Tian, F. - Min, J. - Kaňka, Jiří - Hammond, P. T. - Du, H.
In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers under Static and Dynamic Conditions.
Proceedings of SPIE - FIBER OPTIC SENSORS AND APPLICATIONS XII. Vol. 9480. Washington: SPIE, 2015 - (Udd, E.; Pickrell, G.; Du, H.), s. 9480051-9480059. ISBN 978-1-62841-596-4. ISSN 0277-786X.
[Conference on Fiber Optic Sensors and Applications XII. Baltimore (US), 22.04.2015-23.04.2015]
R&D Projects: GA MŠMT(CZ) LH11038
Institutional support: RVO:67985882
Keywords : long period grating * drug release * polyelectrolyte
Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA](n) polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA] n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA] n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy
Permanent Link: http://hdl.handle.net/11104/0257861