Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

0457459 - ÚFE 2016 RIV US eng J - Journal Article
Tian, F. - Min, J. - Kaňka, Jiří - Li, X. - Hammond, P. T. - Du, H.
Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers.
Optics Express. Roč. 23, č. 15 (2015), s. 20132-20142. ISSN 1094-4087
R&D Projects: GA MŠMT(CZ) LH11038
Institutional support: RVO:67985882
Keywords : long-period grating * drug release * thin film
Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering
Impact factor: 3.148, year: 2015

A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA](n) multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 degrees C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions
Permanent Link: http://hdl.handle.net/11104/0257859