Biological evaluation of ultra-fine titanium with improved mechanical strength for dental implant engineering

0456259 - FZÚ 2016 RIV US eng J - Journal Article
Ostrovská, L. - Vištejnová, L. - Dzugan, J. - Slama, P. - Kubina, T. - Ukraintsev, Egor - Kubies, Dana - Králíčková, M. - Hubálek Kalbáčová, M.
Biological evaluation of ultra-fine titanium with improved mechanical strength for dental implant engineering.
Journal of Materials Science. Roč. 51, č. 6 (2016), s. 3097-3110. ISSN 0022-2461. E-ISSN 1573-4803
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA MZd(CZ) NT13297
Institutional support: RVO:68378271 ; RVO:61389013
Keywords : mesenchymal stem-cells * thermal-stability
Subject RIV: BO - Biophysics; CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 2.599, year: 2016

Titanium, the gold standard for dental implant materials, is distinguished by its exceptional biocompatibility; however, from a long-term perspective, titanium still lacks sufficient loading strength. Commercially pure titanium with grain size 30 mu m was processed by equal channel angular pressing, and two novel mechanically improved types of titanium material with grain size 4.6 and a parts per thousand currency sign1 A mu m were obtained. The surfaces of these ultra-fine grained titanium samples were further mechanically treated by grinding and polishing, and their surfaces were characterized by atomic force microscopy and contact angle measurement. Osteoblast-like cells and human mesenchymal stem cells were used to evaluate the cytocompatibility of these titanium samples. The cell metabolic activity, cell number, cell area, morphology, and cell adhesion quality during the early stage (2 h) and prolonged cultivation (48 h) were determined.
Permanent Link: http://hdl.handle.net/11104/0256819