Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats

0454661 - ÚEM 2016 RIV GB eng J - Journal Article
Amemori, Takashi - Růžička, Jiří - Romanyuk, Nataliya - Jhanwar-Uniyal, M. - Syková, Eva - Jendelová, Pavla
Comparison of intraspinal and intrathecal implantation of induced pluripotent stem cell-derived neural precursors for the treatment of spinal cord injury in rats.
Stem Cell Research & Therapy. Roč. 6, Dec (2015), s. 257. E-ISSN 1757-6512
R&D Projects: GA MŠMT(CZ) LH12024
Institutional support: RVO:68378041
Keywords : spinal cord injury * human induced pluripotent stem cells * cell therapy * cell application route
Subject RIV: FH - Neurology
Impact factor: 4.504, year: 2015

In the present study, we administered neural precursors derived from induced pluripotent stem cells (iPS-NPs) either intraspinally into the lesion center or intrathecally into the subarachnoid space of rats with a balloon-induced spinal cord compression lesion. Both treatments facilitated the functional locomotor recovery of rats with SCI. Intrathecal application of iPS-NPs has a positive therapeutic influence (resulting in locomotor improvement, moderate tissue sparing and axonal sprouting) on SCI through a paracrine mechanism that does not require the presence of cells in the tissue. However, the extended survival of intraspinally grafted cells in the spinal cord may promote long-term spinal cord tissue regeneration.
Permanent Link: http://hdl.handle.net/11104/0255376