Malleable Mitochondrion of Trypanosoma brucei

0453323 - BC 2016 RIV US eng J - Journal Article
Verner, Zdeněk - Basu, Somsuvro - Benz, C. - Dixit, S. - Dobáková, Eva - Faktorová, Drahomíra - Hashimi, Hassan - Horáková, Eva - Huang, Zhenqiu - Paris, Zdeněk - Peña-Diaz, Priscila - Ridlon, L. - Týč, Jiří - Wildridge, David - Zíková, Alena - Lukeš, Julius
Malleable Mitochondrion of Trypanosoma brucei.
International Review of Cell and Molecular Biology. Roč. 315, 2015 Feb 07 (2015), s. 73-151. ISSN 1937-6448
R&D Projects: GA ČR GAP302/12/2513; GA MŠMT LL1205; GA MŠMT(CZ) EE2.3.30.0032; GA MŠMT LH12104; GA ČR GAP305/12/2261
EU Projects: European Commission(XE) 316304
Institutional support: RVO:60077344
Keywords : Kinetoplast * Metabolism * Mitochondrial transport * Mitochondrion * RNA import * T. brucei * Trypanosome * kDNA
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.752, year: 2015

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases. We present a comprehensive survey of its mitochondrial pathways including kinetoplast DNA replication and maintenance, gene expression, protein and metabolite import, major metabolic pathways, Fe-S cluster synthesis, ion homeostasis, organellar dynamics, and other processes. As we describe in this chapter, the single mitochondrion of T. brucei is everything but simple and as such rivals mitochondria of multicellular organisms
Permanent Link: http://hdl.handle.net/11104/0254161