Effect of low doses of herbicide paraquat on antioxidant defense in Drosophila

0451715 - BC 2016 RIV US eng J - Journal Article
Krůček, Tomáš - Korandová, Michala - Szakosová, K. - Šerý, Michal - Čapková Frydrychová, Radmila
Effect of low doses of herbicide paraquat on antioxidant defense in Drosophila.
Archives of Insect Biochemistry and Physiology. Roč. 88, č. 4 (2015), s. 235-248. ISSN 0739-4462. E-ISSN 1520-6327
R&D Projects: GA ČR GA14-07172S
EU Projects: European Commission(XE) 316304 - MODBIOLIN
Grant - others:GA JU(CZ) 038/2014/P; GA JU(CZ) 052/2013/P
Institutional support: RVO:60077344
Keywords : Drosophila * oxidative stress * paraquat
Subject RIV: CE - Biochemistry
Impact factor: 1.357, year: 2015
http://onlinelibrary.wiley.com/doi/10.1002/arch.21222/epdf

Despite a high toxicity, paraquat is one of the most widely used herbicides in the world. The study evaluated the effect of paraquat exposure on antioxidant response in Drosophila melanogaster. When we examined the /nenzymatic activity of superoxide dismutase and catalase in flies exposed to a wide range of paraquat concentrations (0.25 μM to 25 mM), biphasic dose–/nresponse curve with the peak at 2.5 μM paraquat was revealed. Males revealed higher susceptibility to paraquat exposure, displaying higher lethality, increased levels of superoxide dismutase activity, and increased peroxide /nlevels than found in females. Because susceptibility to paraquat was enhanced by mating, the study supports the hypothesis of elevation of stress sensitivity as a physiological cost of reproduction.
Permanent Link: http://hdl.handle.net/11104/0256862