A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera)

0451298 - BC 2016 RIV US eng J - Journal Article
Ribeiro, J.M.C. - Schwarz, Alexandra - Francischetti, I.M.B.
A Deep Insight Into the Sialotranscriptome of the Chagas Disease Vector, Panstrongylus megistus (Hemiptera: Heteroptera).
Journal of Medical Entomology. Roč. 52, č. 3 (2015), s. 351-358. ISSN 0022-2585. E-ISSN 1938-2928
R&D Projects: GA MŠMT LH12002; GA ČR GPP302/11/P798
Institutional support: RVO:60077344
Keywords : Chagas disease * vector biology * salivary gland * transcriptome * medical entomology
Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology
Impact factor: 1.712, year: 2015

Saliva of blood-sucking arthropods contains a complex cocktail of pharmacologically active compounds that assists feeding by counteracting their hosts' hemostatic and inflammatory reactions. Panstrongylus megistus (Burmeister) is an important vector of Chagas disease in South America, but despite its importance there is only one salivary protein sequence publicly deposited in GenBank. In the present work, we used Illumina technology to disclose and publicly deposit 3,703 coding sequences obtained from the assembly of >70 million reads. These sequences should assist proteomic experiments aimed at identifying pharmacologically active proteins and immunological markers of vector exposure.
Permanent Link: http://hdl.handle.net/11104/0252494