Structure and properties of porous films based on aliphatic copolyamide developed for cellular technologies

0451058 - ÚSMH 2016 RIV GB eng J - Journal Article
Dobrovol`skaya, I.P. - Popryadukhin, P.V. - Yudin, V. E. - Ivankova, E.M. - Elokhovskiy, V.Y. - Weishauptová, Zuzana - Balík, Karel
Structure and properties of porous films based on aliphatic copolyamide developed for cellular technologies.
Journal of Materials Science-Materials in Medicine. Roč. 26, č. 1 (2015), article number 46. ISSN 0957-4530. E-ISSN 1573-4838
Institutional support: RVO:67985891
Keywords : porous film * aliphatic copolyamide * structure * properties
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.272, year: 2015
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The effect of concentration and viscosity of the copolyamide (copolymer of epsilon-caprolactam and hexamethylendiaminadipate) solutions in aqueous/alcoholic solvents on its phase state was studied. The films obtained by the coagulation method were characterized by monodisperse pore distribution with an average pore size of 1.3 mu m. The films processed by electrospinning from copolyamide solutions were characterized by a bimodal distribution of macropores with one peak of pore radius at 2.0 mu m and second peak of pore radius at 20 mu m. The adhesion and proliferation of mesenchymal adhesion stem cells (ASCs) stem cells to copolyamide matrix were studied. With the help of scanning electron microscopy it was shown that both tapes porous films were characterized by good adhesion of mesenchymal ASCs stem cells. It was shown that the porous structure, transport and mechanical properties of these copolyamide films allow their use as two-dimensional matrices for cellular technology.
Permanent Link: http://hdl.handle.net/11104/0252253